Publication Articles

Medium and Large Vessel Vasculitis: Recognizing Patterns on FDG PET-CT

(RSNA 2018, Sun Nov 25 2018 11:35AM - 11:45AM ROOM Z44) PURPOSE The diagnosis of medium to large-vessel vasculitis and the assessment of its activity and extent remain challenging. We assess the clinical utility of FDG PET CT in patients with suspected medium and large vessel vasculitis to evaluate the pattern and extent of vessel involvement. METHOD AND MATERIALS 100 consecutive patients (64 males and 36 females) with suspected medium and large-vessel vasculitis were evaluated with FDG PET/CT. FDG uptake in the major vessels was visually graded using a four-point scale and quantified with standardised uptake values (SUV max). Patients were further sub-divided into three groups: (a) steroid-naive medium to large-vessel vasculitis (N=34, 69% of total positive patients), (b) vasculitis on steroid treatment (N=15, 30.6% of total positive patients) and (c) no evidence of vasculitis (N=51). Analysis of variance and linear regression were used to investigate the association of FDG uptake with clinical parameters. RESULTS FDG-PET revealed pathological findings in 49 of 100 patients. FDG PET/CT was positive (visual uptake >2; equal to or greater than liver) in all patients with steroid-naive medium to large-vessel vasculitis. The thoracic aorta, the carotid and the subclavian arteries were most frequently involved. In these patients, SUVmax values were significantly higher than in the other groups. CONCLUSION FDG PET is a sensitive and specific imaging tool for medium and large vessel vasculitis, especially when performed in steroid naive patients. It increases the overall diagnostic accuracy and has an impact on the clinical management in a significant proportion of patients. CLINICAL RELEVANCE/APPLICATION FDG-PET should be used in diagnosis and characterisation of medium and large vessel vasculitis to determine optimal treatment methodologies.